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Follistatin 344 (FS-344) 1mg is a synthetic research peptide used to inhibit myostatin, a protein that restricts muscle growth, potentially increasing muscle mass, strength, and regeneration. It is frequently used in studies regarding muscle-wasting diseases, tissue repair, and, in some animal models,, to improve longevity. It is not approved for human consumption and is for laboratory use only

1. Myostatin & Activin Inhibition

FST-344 acts as a natural antagonist to myostatin (GDF-8) and activins—key negative regulators of muscle growth and tissue differentiation. By blocking these ligands, it enables investigation into muscle hypertrophy and cellular development.

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2. Muscle Hypertrophy & Regeneration

In preclinical models, including mice and primates, FST-344 has been shown to promote muscle fiber growth, preserve muscle mass, and activate anabolic signaling (e.g., via Akt/mTOR)—making it a valuable candidate for studying muscle wasting and recovery mechanisms.

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3. Tissue Rebuilding & Fibrosis Modulation

By neutralizing activin, FST-344 may facilitate tissue regeneration and reduce fibrosis. Animal studies indicate potential to limit liver fibrosis and enhance tissue repair pathways.

4. Metabolic & Endocrine Modulation

Emerging research in diabetes models suggests Fst overexpression may improve pancreatic β-cell mass, glucose regulation, and insulin-related pathways, indicating the peptide’s broader influence on metabolic research settings.

5. Tumor Microenvironment & TGF-β Regulation

FST-344’s modulation of TGF-β ligand signaling may affect tumor cell behavior, including proliferation, metastasis, and drug resistance, making it relevant in emerging oncology-focused extracellular milieu studies.

Conclusion

Follistatin-344 is a versatile research-grade peptide for probing the roles of TGF-β regulators in muscle growth, tissue repair, metabolic regulation, and cancer biology. Supplied strictly for research use only, it is not intended for human or veterinary application.

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Technical Information:

• Synonyms: Follistatin-344; FST-344; Activin-binding protein

• Molecular Weight: ~3780 g/mol

• CAS Number: 53‑84‑9

• PubChem CID: 178101631

• Further References: PubChem Entry

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Stability, Source, and Handling

• Stability: Stable for up to 36 months at –20 °C or lower, protected from light and moisture.

• Source: Synthesized via solid-phase peptide techniques; high-purity synthesis with Certificate of Analysis (COA) confirmation.

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 Reconstitution: Reconstitute in sterile water or PBS under aseptic conditions; aliquot and store at –80 °C after reconstitution to preserve activity. Reconstitute with Bacteriostatic Water

• Usage: Product is prepared for LABORATORY RESEARCH ONLY.

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