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Dihexa, also known as N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, or its developmental code name PNB-0408, is an oligopeptide drug derived from angiotensin IV. It binds with high affinity to hepatocyte growth factor (HGF) and interacts with its receptor, c-Met.

The molecular formula of Dihexa is C27H44N4O5, with a molar mass of 504.672 g·mol−1.

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Dihexa consists of two hydrophobic amino acids—Tyr-Ile—with the full sequence as follows: Hexanoyl-Tyr-Ile-Ahx-NH₂.

Solubility Information

Important: Due to its hydrophobic nature, Dihexa does not dissolve in pure water and must be mixed with a suitable solvent such as DMSO. This is essential for proper reconstitution.

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Based on laboratory testing and published research:

• Dihexa dissolves well in DMSO at a concentration of 1mg/ml
  • Adding 1ml of pure water may cause the solution to become cloudy.
  • Applying ultrasonic treatment for 2 seconds typically clears the solution.

  This solubility profile influences the format in which Dihexa is supplied for research. Researchers intending to work with the lyophilised version should ensure access to DMSO or a similar solvent for proper handling.

  Storage Guidelines

  Store the lyophilised peptide at -20°C. Once reconstituted, use it immediately or store it at 2–8°C for a short duration. Avoid repeated freeze-thaw cycles.

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  Disclaimer: This product is intended for laboratory research use only. It is not approved for human or veterinary use.